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Metformin Extended-Release vs Immediate-Release: Which Is Easier on Your Stomach?

Metformin Extended-Release vs Immediate-Release: Which Is Easier on Your Stomach?

Metformin extended-release (XR) reduces stomach side effects compared to immediate-release (IR) for many people with type 2 diabetes. Learn how the two versions differ, what the data shows, and how to switch safely.

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Jan 10, 2026 by Sara Hooshyar

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